When Jesus addresses the church in Pergamum, he says that he knows where they live, where “Satan has his throne.” In our book, I discuss possible interpretations of this phrase:

This statement has led to much speculation over the years as to what could be considered to be “Satan’s throne.” Some would point to the temple of Asclepios. Certainly the serpent god of the Romans could be connected with the ancient serpent which tempted Eve in the Garden of Eden. Yet the temple of Asclepios was a center of healing and medicine, hardly an evil place in and of itself. There’s nothing to make us think that the things that went on there would have been of any threat to the Christians. Another possibility that is often mentioned is the huge altar to Zeus which could be seen looming above the city. Zeus was considered king of the Roman gods, and the altar contained images of the whole pantheon of gods and goddesses. Its imagery would have been offensive to Christians as would have been the activities which went on there. Still, there’s little to make us connect this pagan building with the context of Revelation; the persecution that was to come upon the Christians did not emanate from this great building. What seems the most likely, given the historical situation in which the first-century Christians in Asia found themselves, is that Paul is referring to Pergamum as provincial capital. The Roman government had established its center in Pergamum and all official persecution of Christians in Asia would originate there. There were a whole series of temples in Pergamum which were dedicated to the different Roman emperors. Emperor worship with its ensuing persecution of Christians; surely that could be considered to be the seat of satanic power in the region. The emperor must not be worshiped, for his power is not of divine origin, but demonic.

(Letters From The Lamb, pp. 81-82)

In his Experimental Theology blog, Richard Beck had an interesting post on the relationship between the demonic powers and earthly governments. (as well as a follow up post on the angels of the nations). This concept is plainly seen in the letter to the church in Pergamum.

Rome’s throne is Satan’s throne. Christians were not in a struggle against mere men; the earthly power that presented itself as an authority was a challenge to God’s authority. It was a representative of Satan on earth.